Zerit – treatment of infection caused by HIV, with severe clinical manifestations and ineffectiveness or intolerance of zidovudine, and other antiretroviral drugs. The nucleoside analogue of thymidine is phosphorylated by cellular enzymes to its active form – stavudine triphosphate. Suppresses reverse transcriptase of HIV, cellular DNA polymerases (beta and gamma), inhibits the synthesis of viral and mitochondrial DNA. It is active against HIV-1.